Dystonia Translational Research and Therapy Consortium

  • explore phenotypic variability and frequency of mutations in known dystonia genes
  • define endophenotypes using neuroimaging or electrophysiology
  • identify novel disease genes

Dystonia Translational Research and Therapy Consortium

  • elucidate disease mechanisms and identify possible biomarkers and drug targets
  • understand environmental factors
  • understand mechanisms of compensation in nonmanifesting mutation carriers

Dystonia Translational Research and Therapy Consortium

  • identify common final pathophysiological pathways of dystonic motor symptoms
  • compare the efficacy of botulinum toxin injection and deep brain stimulation in controlling dystonia-related disability