Dystonia Translational Research and Therapy Consortium


  • explore phenotypic variability and frequency of mutations in known dystonia genes
  • define endophenotypes using neuroimaging or electrophysiology

Dystonia Translational Research and Therapy Consortium


  • identify novel disease genes
  • elucidate disease mechanisms and identify possible biomarkers and drug targets

Dystonia Translational Research and Therapy Consortium


  • identify common final pathophysiological pathways of dystonic motor symptoms
  • compare the efficacy of botulinum toxin injection and deep brain stimulation in controlling dystonia-related disability

Dystonia Translational Research and Therapy Consortium


  • understand environmental factors
  • understand mechanisms of compensation in nonmanifesting mutation carriers

Dystonia Translational Research and Therapy Consortium


BMBF eng kleinDYSTRACT is funded
by the German Federal Ministry
of Education and Research.
(2015-2018)